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Mitochondrial targeting of tBid
Correspondence: B Zhivotovsky, Division of Toxicology, Institute of Environmental Medicine, Karolinska Institutet, Box 210, SE 171 77 Stockholm, Sweden.
Top of pageAbstractThe release of pro apoptotic proteins from online pandora charms the mitochondria is a key event in cell death signaling that is regulated by Bcl 2 family proteins. For example, cleavage of the BH3 only protein, Bid, by multiple proteases leads to the formation of truncated Bid that, in turn, promotes the insertion of Bax into the mitochondrial outer membrane, resulting in pore formation and the release of proteins residing in the intermembrane space. Bax, a monomeric protein in the cytosol is targeted pandora sister charm australia to the mitochondria by a yet unknown mechanism.
Several proteins jared galleria of jewelry of the outer mitochondrial membrane have been proposed to act as receptors for Bax, among them the voltage dependent anion channel, VDAC, and the mitochondrial protein translocase of the outer membrane, the TOM complex. Alternatively, the unique mitochondrial phospholipid, cardiolipin, has been ascribed a similar function. Here, we review recent work on the mechanisms of activation and the targeting pandora bead watch of Bax to the mitochondria and discuss the advantages and limitations of the methods used to study this process.
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